Little Big Town took part in the star-studded Stand Up to Cancer telecast on Sept. 7 that was broadcast across more than 70 TV networks.

The live one-hour fundraiser, which was Stand Up to Cancer’s sixth event since 2008, featured a number of stars, including Jason Bateman, Kathy Bates, Josh Brolin, Katie Couric, Kaley Cuoco, Jennifer Garner, Jon Hamm, Matthew McConaughey, Keanu Reeves, Winona Ryder, Sofia Vergara, Matt Damon, Bradley Cooper and more.

This year’s event raised more that $123 million in pledges, bringing SU2C’s total to more than $603 million over 10 years.

Little Big Town performed “With a Little Help From My Friends,” a tune that the Beatles originally recorded in 1967 and Joe Cocker covered in 1968.

Watch Little Big Town’s performance below, which begins at the 5:20 mark.